Experimental pathogenicity evaluation of Mycoplasma canadense from bovine mastitis in vitro and in vivo laboratory models.

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dc.contributor.authorGarg, D Nen_US
dc.contributor.authorSingh, Yen_US
dc.contributor.authorYadav, Ren_US
dc.contributor.authorMahajan, S Ken_US
dc.date.accessioned2009-05-28T12:55:21Z
dc.date.available2009-05-28T12:55:21Z
dc.date.issued2004-02-31en_US
dc.description.abstractMycoplasma canadense, a clinical isolate from milk of a mastitic buffalo, was experimentally tested for its pathogenic potential in hamster tracheal ring and rabbit fallopian tube explant organ cultures (in vitro) and rat and rabbit mammary gland (in vivo) models. The activity percentage reduction in M. canadense infected hamster tracheal rings was 99.1% in comparison to 16.4% in control rings. Mycoplasma canadense, also induced complete ciliostasis at 11-day post-infection in rabbit fallopian tube explants. Histopathological lesions in these infected organ cultures were loss of cilia, desquamation or denudation of epithelium, infiltration of inflammatory cells and proliferation of macrophages as well as oedema in lamina propria. At the end of the experiments, M. canadense organisms were reisolated in pure colonies from the infected but not the control organ cultures. In the rat and rabbit mammary glands, M. canadense organisms persisted upto 6-day and 7-day postinfection, respectively and caused histopathological changes suggestive of subacute to chronic mastitis during the experimental period. The results indicate that the tested M. canadense clinical isolate was virulent.en_US
dc.description.affiliationDepartment of Veterinary Public Health, CCS Haryana Agricultural University, Hisar, India. dng123@hau.nic.inen_US
dc.identifier.citationGarg DN, Singh Y, Yadav R, Mahajan SK. Experimental pathogenicity evaluation of Mycoplasma canadense from bovine mastitis in vitro and in vivo laboratory models. Indian Journal of Experimental Biology. 2004 Feb; 42(2): 152-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58728
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCattleen_US
dc.subject.meshCattle Diseases --microbiologyen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCiliaen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshEdemaen_US
dc.subject.meshEpitheliumen_US
dc.subject.meshFallopian Tubes --microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMacrophagesen_US
dc.subject.meshMastitis --microbiologyen_US
dc.subject.meshMilk --microbiologyen_US
dc.subject.meshMycoplasma --isolation & purificationen_US
dc.subject.meshMycoplasma Infections --microbiologyen_US
dc.subject.meshOrgan Culture Techniquesen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.subject.meshTrachea --microbiologyen_US
dc.titleExperimental pathogenicity evaluation of Mycoplasma canadense from bovine mastitis in vitro and in vivo laboratory models.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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