In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic.

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dc.contributor.authorAlam, M Aen_US
dc.contributor.authorAwal, M Aen_US
dc.contributor.authorSubhan, Nen_US
dc.contributor.authorMostofa, Men_US
dc.date.accessioned2009-02-03en_US
dc.date.accessioned2009-05-27T03:49:47Z
dc.date.available2009-02-03en_US
dc.date.available2009-05-27T03:49:47Z
dc.date.issued2009-02-03en_US
dc.descriptionJournal of Health, Population, and Nutrition.en_US
dc.description.abstractThe degree of binding of a drug to plasma proteins has a marked effect on its distribution, elimination, and pharmacological effect since only the unbound fraction is available for distribution into extra-vascular space. The protein-binding of atenolol was measured by equilibrium dialysis in the bovine serum albumin (BSA). Free atenolol concentration was increased due to addition of arsenic which reduced the binding of the compounds to BSA. During concurrent administration, arsenic displaced atenolol from its high-affinity binding Site I, and free concentration of atenolol increased from 4.286 +/- 0.629% and 5.953 +/- 0.605% to 82.153 +/- 1.924% and 85.486 +/- 1.158% in absence and presence of Site I probe respectively. Thus, it can be suggested that arsenic displaced atenolol from its binding site resulting in an increase of the free atenolol concentration in plasma.en_US
dc.description.affiliationDepartment of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka 1217, Bangladesh. sonaliagun@yahoo.comen_US
dc.identifier.citationAlam MA, Awal MA, Subhan N, Mostofa M. In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic. Journal of Health, Population, and Nutrition. 2009 Feb; 27(1): 20-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/685
dc.language.isoengen_US
dc.source.urihttps://www.icddrb.org/pub/publication.jsp?classificationID=30&typeClassificationID=2en_US
dc.subject.meshAdrenergic beta-Antagonists --chemistryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArsenic --chemistryen_US
dc.subject.meshAtenolol --chemistryen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshBinding, Competitiveen_US
dc.subject.meshBiological Availabilityen_US
dc.subject.meshCattleen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshHumansen_US
dc.subject.meshSerum Albumin --chemistryen_US
dc.titleIn-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic.en_US
dc.typeJournal Articleen_US
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