Clinicopathological Characteristics of Pernicious Anemia: A Study of 300 Patients in Turkey.

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dc.contributor.authorBentli, Recep
dc.contributor.authorBerber, Ilhami
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorAydogdu, Ismet
dc.contributor.authorGunduz, Ercan
dc.contributor.authorNizam, Ilknur
dc.contributor.authorKaya, Emin
dc.contributor.authorKuku, Irfan
dc.contributor.authorKoroglu, Mustafa
dc.date.accessioned2016-03-02T06:57:50Z
dc.date.available2016-03-02T06:57:50Z
dc.date.issued2014-01-21
dc.description.abstractAims: Our study was undertaken to examine the laboratory and clinical features of pernicious anemia patients presenting initially at the Turgut Ozal Medical Center, which serves as an important tertiary health center in Eastern Anatolia. Study Design: Among patients evaluated for etiology of anemia, we analysed the clinicopathological characteristics of 300 (158 females and 142 males) patients with pernicious anemia retrospectively. Place and Duration of Study: Department of Internal Medicine and Division of Hematology, Inonu University School of Medicine, between 1996 and July 2011. Methodology: Full blood counts, thyroid hormone levels, liver function tests and LDH levels were reviewed for 300 patients with pernicious anemia retrospectively. Peripheral blood smears and bone marrow biopsies were reviewed by a hematologist. Endoscopic examination and ultrasonographic inspection were performed for atrophic gastritis, gallbladder stones and hepatosplenomegaly for all patients. Laboratory values, ages, signs and symptoms of patients at the time of diagnosis were compared between genders. Results: The mean age of the female patients was 50.56 ± 17.75 years (17–84), while that of the male patients was 57.24 ± 15.78 (20–95) years. At the time of diagnosis, the male patients were older than the females (p = 0.002). LDH levels were significantly higher for females (p = 0.043). The incidence of gallstones was significantly higher in females (25.4%) than in males (10.7%) (p = 0,001). Pancytopenia was defined as a hemoglobin level lower than 10 gr/dl, leukocytes lower than 1.500/μL and platelets lower than 150.000/μL and the incidence of pancytopenia was 41.3% (n = 65) and 50.7% (n = 71) in the female and male patients, respectively, and the difference was not statistically significant. There was no statistically significant difference for frequency of thyroid disease or symptoms and signs at the time of diagnosis between genders. Conclusions: Pernicious anemia is not a disease of only elderly women; it can be seen in both men and women of younger ages. It is seen nearly as often in women as in men. Gallstones and abnormal thyroid activity can be observed at these patients at the time of diagnosis; therefore, these findings should be considered.en_US
dc.identifier.citationBentli Recep, Berber llhami, Erkurt Mehmet Ali, Aydogdu Ismet, Gunduz Ercan, Nizam llknur, Kaya Emin, Kuku Irfan, Koroglu Mustafa. Clinicopathological Characteristics of Pernicious Anemia: A Study of 300 Patients in Turkey. British Journal of Medicine and Medical Research. 2014 Jan; 4(3): 807-815.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/174960
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/2331en_US
dc.subjectPerniciousen_US
dc.subjectanemiaen_US
dc.subjectclinicopathologicen_US
dc.subjectgenderen_US
dc.titleClinicopathological Characteristics of Pernicious Anemia: A Study of 300 Patients in Turkey.en_US
dc.typeArticleen_US
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