Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.

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dc.contributor.authorTripathi, Rachanaen_US
dc.contributor.authorKota, Satya Keerthien_US
dc.contributor.authorSrinivas, Usha Ken_US
dc.date.accessioned2007-09-24en_US
dc.date.accessioned2009-06-01T14:35:16Z
dc.date.available2007-09-24en_US
dc.date.available2009-06-01T14:35:16Z
dc.date.issued2007-09-24en_US
dc.description.abstractBeta-catenin is the key transducer of Wingless-type MMTV integration site family member (Wnt) signalling, upregulation of which is the cause of cancer of the colon and other tissues. In the absence of Wnt signals, beta-catenin is targeted to ubiquitin-proteasome-mediated degradation. Here we present the functional characterization of E3-ubiquitin ligase encoded by cul4B. RNAi-mediated knock-down of Cul4B in a mouse cell line C3H T10 (1/2) results in an increase in beta-catenin levels. Loss-of-function mutation in Drosophila cul4 also shows increased beta-catenin/Armadillo levels in developing embryos and displays a characteristic naked-cuticle phenotype. Immunoprecipitation experiments suggest that Cul4B and beta-catenin are part of a signal complex in Drosophila, mouse and human. These preliminary results suggest a conserved role for Cul4B in the regulation of beta-catenin levels.en_US
dc.description.affiliationCentre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.en_US
dc.identifier.citationTripathi R, Kota SK, Srinivas UK. Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin. Journal of Biosciences. 2007 Sep; 32(6): 1133-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110932
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Genetically Modifieden_US
dc.subject.meshArmadillo Domain Proteins --antagonists & inhibitorsen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCullin Proteins --geneticsen_US
dc.subject.meshDown-Regulation --geneticsen_US
dc.subject.meshDrosophila Proteins --antagonists & inhibitorsen_US
dc.subject.meshDrosophila melanogaster --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLarva --geneticsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C3Hen_US
dc.subject.meshTranscription Factors --antagonists & inhibitorsen_US
dc.subject.meshUbiquitin-Protein Ligases --physiologyen_US
dc.subject.meshbeta Catenin --antagonists & inhibitorsen_US
dc.titleCullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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