Comparative detoxification and protection of scorpion (Heterometrus bengalensis) venom by toxoid antiserum.

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dc.contributor.authorDas Gupta, S Cen_US
dc.contributor.authorGomes, Aen_US
dc.contributor.authorGomes, Aen_US
dc.contributor.authorBasu, Aen_US
dc.contributor.authorLahiri, S Cen_US
dc.date.accessioned2009-05-28T14:22:27Z
dc.date.available2009-05-28T14:22:27Z
dc.date.issued1989-06-01en_US
dc.description.abstractComparative detoxification of scorpion venom by using different chemical agents was investigated. Detoxification by formalin showed the best optimum detoxifying agent. The formalin treatment resulted in 2.3% protein loss with 6-fold detoxification. This formal toxoid was immunogenic in rabbit giving high neutralizing antibodies as revealed from indirect haemagglutination test. Toxoid antiserum protected mice against the lethal action of venom. It also effectively antagonized the smooth muscle contractile response of venom, and venom-induced neuromuscular paralysis. This toxoid antiserum also protected the venom-induced cardiac arrest. The possibility of using this formal toxoid for antisera production and immunization for therapeutic use needs to be explored.en_US
dc.identifier.citationDas Gupta SC, Gomes A, Gomes A, Basu A, Lahiri SC. Comparative detoxification and protection of scorpion (Heterometrus bengalensis) venom by toxoid antiserum. Indian Journal of Experimental Biology. 1989 Jun; 27(6): 568-73en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60625
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntivenins --pharmacologyen_US
dc.subject.meshFormaldehydeen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMiceen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMyocardial Contractionen_US
dc.subject.meshRatsen_US
dc.subject.meshScorpion Venoms --antagonists & inhibitorsen_US
dc.subject.meshScorpionsen_US
dc.subject.meshSwineen_US
dc.subject.meshThioctic Acid --analogs & derivativesen_US
dc.subject.meshToxoids --immunologyen_US
dc.titleComparative detoxification and protection of scorpion (Heterometrus bengalensis) venom by toxoid antiserum.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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