A Study of the effect of tea on the metabolism of caffeine
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Date
1982
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Publisher
University of Colombo: UC(MED).
Abstract
Tissue distribution studies of (1-methyl - C14) caffeine showed that caffeine was readily absorbed from the gastrointestinal tract. The peak blood level of radioactivity was observed 3 hours after oral administration. The blood level then rapidly declined. When caffeine was administrated with tea infusion, the peak radioactivity in blood was reached after 6 hours. The blood level remained high over long period. Liver, kidney, testes and heart muscles showed high level of radioactivity. When caffeine was administrated with tea, the tissue distribution profile showed a biphasic pattern. Highest content of radioactivity was associated with the testes. Following oral administration of (1- methyl - C14) caffeine to rats, the drug or its metabolites were excreted in urine. Approximately 62 percent of the administrated radioactivity was excreted by male rats. While females excreted approximately 67 percent. The greater part of urinary excretion in both sexes occurred during 12 - 24 hours. Small amounts (6 - 10 percent) of radioactivity were detected in faeces. Administration of caffeine with tea infusion resulted in an increase in urinary excretion in both sexes. The overall results tissue distribution, excretion and metabolism studies of pure caffeine and caffeine with tea, suggested a possible reduction in the bioavailability of caffeine by other component(s) in tea.
Description
Dissertation: M.Sc., University of Colombo: UC(MED), 1982.
Keywords
Caffeine
Citation
JAYAWARDENA, SSSBDP, A Study of the effect of tea on the metabolism of caffeine, University of Colombo UC(MED), 1982: 94p.