Metronomic therapy: Chemotherapy revisited.

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dc.contributor.authorNoronha, V
dc.contributor.authorKrishna, M V
dc.contributor.authorPatil, V
dc.contributor.authorJoshi, A
dc.contributor.authorBanavali, S D
dc.contributor.authorPrabhash, K
dc.date.accessioned2013-10-04T08:35:18Z
dc.date.available2013-10-04T08:35:18Z
dc.date.issued2013-04
dc.description.abstractCytotoxic antiproliferative chemotherapeutic agents are the mainstay of treatment in cancers. Chemotherapy is usually administered every 2–3 weeks. Along with acute toxicity and long‑term effects of cumulative doses, this strategy potentially allows regrowth of the tumor in the interval period and leads to the emergence of resistant populations of tumor cells. Moreover, even with intense chemotherapy, the outcome is stagnating for most of the tumors. There has been recent interest in the use of chemotherapy in fractionated doses which is far below the maximum tolerated dose. This is called metronomic scheduling of chemotherapy. Here, we review the biology and evidence for metronomic chemotherapy.en_US
dc.identifier.citationNoronha V, Krishna M V, Patil V, Joshi A, Banavali S D, Prabhash K. Metronomic therapy: Chemotherapy revisited. Indian Journal of Cancer. 2013 Apr-June; 50(2): 142-148.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148639
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2013;volume=50;issue=2;spage=142;epage=148;aulast=Noronhaen_US
dc.subjectChemotherapyen_US
dc.subjectmetronomicsen_US
dc.subjecteconomicsen_US
dc.subject.meshAdministration, Metronomic
dc.subject.meshAngiogenesis Inhibitors --therapeutic use
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic use
dc.subject.meshHumans
dc.subject.meshNeoplasms --drug therapy
dc.subject.meshNeoplasms --economics
dc.subject.meshNeoplasms --pathology
dc.subject.meshNeovascularization, Pathologic --drug therapy
dc.subject.meshNeovascularization, Pathologic --pathology
dc.titleMetronomic therapy: Chemotherapy revisited.en_US
dc.typeArticleen_US
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