Inducible clindamycin resistance in Staphylococcus aureus: Reason for treatment failure.

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dc.contributor.authorSathish, J V
dc.contributor.authorJanakiram, K
dc.contributor.authorVijaya, D
dc.date.accessioned2015-09-15T05:15:47Z
dc.date.available2015-09-15T05:15:47Z
dc.date.issued2015-08
dc.description.abstractEmergence of methicillin resistance in Staphylococcus aureus (S.aureus) has left us with very few therapeutic alternatives available to treat staphylococcal infection. The widespread use of macrolide-lincosamide-streptogramin B (MLSB) antibiotics has led to an increase in number of staphylococcal strains acquiring resistance to MLSB antibiotics. This study was done to investigate the infections by hospital and community acquired “erythromycin- induced clindamycin resistant” strains or D-test positives of clinical isolates of Staphylococcus aureus (S.aureus) in a hospital. Three hundred isolates of S.aureus were subjected to routine antibiotic susceptibility testing including Cefoxitin (30µg) by modified disc diffusion method. Inducible resistance to clindamycin in S.aureus was tested by D-test as per CLSI guidelines. Among 300 S.aureus isolates, 114 (38%) were methicillin resistant Staphylococcus aureus (MRSA) and 186 (62%) methicillin susceptible Staphylococcus aureus (MSSA). Forty one (13.67%) isolates showed induced clindamycin resistance, 49(16.33%) showed constitutive resistance and 94 (31.33%) showed the MS phenotype. Inducible resistance and constitutive resistance were found to be higher in MRSA compared to MSSA (22.81%, 23.68% and 8.1%, 11.8% respectively). D-test should be included as a part of routine antibiotic susceptibility testing to detect induced clindamycin resistance to prevent treatment failure.en_US
dc.identifier.citationSathish J V, Janakiram K, Vijaya D. Inducible clindamycin resistance in Staphylococcus aureus: Reason for treatment failure. Journal of International Medicine and Dentistry. 2015 Aug; 2(2): 97-103.en_US
dc.identifier.issn2350-045X
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/163459
dc.language.isoenen_US
dc.source.urihttps://www.jimd.in/journals/issues/view/JIMD/2015/65en_US
dc.subjectErythromycinen_US
dc.subjectClindamycinen_US
dc.subjectD-testen_US
dc.subjectMRSAen_US
dc.subjectMSSAen_US
dc.subject.meshClindamycin --pharmacology
dc.subject.meshErythromycin --pharmacology
dc.subject.meshDrug Resistance, Bacterial
dc.subject.meshMethicillin-Resistant Staphylococcus aureus --drug effects
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshSensitivity and Specificity
dc.subject.meshStaphylococcus aureus --drug effects
dc.subject.meshTreatment Failure
dc.titleInducible clindamycin resistance in Staphylococcus aureus: Reason for treatment failure.en_US
dc.typeArticleen_US
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