Adjuvant therapy in cerebral malaria.

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dc.contributor.authorMohanty, Sanjiben_US
dc.contributor.authorPatel, D Ken_US
dc.contributor.authorPati, S Sen_US
dc.contributor.authorMishra, S Ken_US
dc.date.accessioned2006-09-07en_US
dc.date.accessioned2009-05-27T08:53:32Z
dc.date.available2006-09-07en_US
dc.date.available2009-05-27T08:53:32Z
dc.date.issued2006-09-07en_US
dc.description82 references.en_US
dc.description.abstractCerebral malaria is the most common cause of non-traumatic encephalopathy in the world. The mainstay of therapy is either quinine or artemisinin, both of which are effective antimalarials. The clinical picture of cerebral malaria may persist or even become worse in spite of the clearance of parasites from blood. The death rate is unacceptably high even with effective antimalarials in tertiary care hospitals. The mortality increases in presence of multi organ failure (renal failure, jaundice, respiratory distress, severe anaemia, lactic acidosis, etc.). The pathogenesis of cerebral malaria is multifactorial and includes clogging, sequestration, rosette formation, release of cytokines, cerebral oedema, increased intracranial hypertension, etc. Attempts are made to use adjuvant therapy which will act through alternate mechanisms and address one or more of the pathogenetic processes. In this review, we have discussed the role of corticosteroids, pentoxifylline, desferrioxamine, mannitol and newer agents in the treatment of cerebral malaria. Though the literature on adjuvant therapy in cerebral malaria is large enough, there are a number of shortcomings in the clinical trials, many being open and non randomized or of very small sample size. Further research is of utmost importance through large multicentric, double-blind controlled trials to show the efficacy of any of these drugs.en_US
dc.description.affiliationDepartments of Medicine and Critical Care Unit, Ispat General Hospital, Rourkela 769005, India. sanjibmalaria@rediffmail.comen_US
dc.identifier.citationMohanty S, Patel DK, Pati SS, Mishra SK. Adjuvant therapy in cerebral malaria. Indian Journal of Medical Research. 2006 Sep; 124(3): 245-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25985
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdrenal Cortex Hormones --therapeutic useen_US
dc.subject.meshAntimalarials --therapeutic useen_US
dc.subject.meshBlood-Brain Barrier --physiopathologyen_US
dc.subject.meshChemotherapy, Adjuvant --methodsen_US
dc.subject.meshDeferoxamine --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria, Cerebral --drug therapyen_US
dc.subject.meshMannitol --therapeutic useen_US
dc.subject.meshPentoxifylline --therapeutic useen_US
dc.titleAdjuvant therapy in cerebral malaria.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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