Pulmonary mycosis in asthma-chronic obstructive pulmonary disease overlap syndrome

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dc.contributor.authorGupta, Ren_US
dc.contributor.authorSingla, Pen_US
dc.contributor.authorGoel, Nen_US
dc.contributor.authorGupta, Aen_US
dc.contributor.authorGupta, Ren_US
dc.contributor.authorSingla, Aen_US
dc.date.accessioned2020-09-24T07:56:47Z
dc.date.available2020-09-24T07:56:47Z
dc.date.issued2020-02
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) and asthma are the two most commonly seen obstructive airway disorders, affecting millions of people across the world. Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) includes the patients having features of both COPD and asthma. Objectives: The objectives of the study were to evaluate spectrum of fungal infection in sputum/induced sputum/bronchoalveolar lavage (BAL) samples of ACOS patients. Materials and Methods: Our prospective study conducted on 80 patients diagnosed ACOS, in exacerbation, of either sex attending the Department of Respiratory Medicine, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, after taking permission from the ethical committee. Sputum or induced sputum or BAL sample was collected in sterile vials and sent to the microbiology department for the examination for fungal species. In microbiology, sputum/BAL samples were subjected to direct microscopic examination using KOH and cultured on Sabouraud Dextrose Agar. The culture was observed daily until 21 days for any fungal growth. Results: Out of 80 patients of ACOS, 43 were males and 37 were females. Culture results were positive for fungal species in 33 patients out of 80 patients (41.2%). Different species of fungi were cultured such as Candida (22.6%), Aspergillus flavus (5%), Aspergillus fumigatus (2.5%), Aspergillus niger (2.5%), Penicillium non-marneffei (3.8%), Trichosporon spp. (3.8%), and Geotrichum spp. (1.3%). Conclusion: Our observations show that a wide spectrum of fungal species is prevalent in respiratory tract in ACOS patients. Determination of pulmonary mycosis in ACOS is required to detect, and treat the coinfection with fungus well in time and decrease morbidity and mortality due to ACOS.en_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, Indiaen_US
dc.identifier.affiliationsNDMC Medical College, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, Indiaen_US
dc.identifier.citationGupta R, Singla P, Goel N, Gupta A, Gupta R, Singla A. Pulmonary mycosis in asthma-chronic obstructive pulmonary disease overlap syndrome. International Journal of Medical Science and Public Health. 2020 Feb; 9(2): 134-138en_US
dc.identifier.issn2277-338X
dc.identifier.issn2320-4664
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205600
dc.languageenen_US
dc.publisherInternational Journal of Medical Science and Public Healthen_US
dc.relation.issuenumber2en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.5455/ijmsph.2020.1132730112019en_US
dc.subjectAsthma-chronic Obstructive Pulmonary Disease Overlap syndromeen_US
dc.subjectPulmonary Mycosisen_US
dc.subjectFungien_US
dc.titlePulmonary mycosis in asthma-chronic obstructive pulmonary disease overlap syndromeen_US
dc.typeJournal Articleen_US
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