Prevention of hypotension during propofol induction: a comparison of preloading with 3.5% polymers of degraded gelatin (Haemaccel) and intravenous ephedrine.

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dc.contributor.authorDhungana, Yen_US
dc.contributor.authorBhattarai, B Ken_US
dc.contributor.authorBhadani, U Ken_US
dc.contributor.authorBiswas, B Ken_US
dc.contributor.authorTripathi, Men_US
dc.date.accessioned2009-05-28T04:25:45Z
dc.date.available2009-05-28T04:25:45Z
dc.date.issued2008-03-15en_US
dc.descriptionNepal Medical College Journal.en_US
dc.description.abstractThe present study compared the efficacy of preloading with colloid "Haemaccel" with vasoconstrictor (intravenous ephedrine sulphate) in preventing hypotension during propofol induction. This prospective, randomized study included 120 patients of Amercan Society of Anaesthesiologists (ASA) physical status I and II ageing 21 to 50 years of both gender coming for routine surgery. Patients were randomly allocated into three groups with 40 patients in each. Group A (control) did not receive any study medication, group B received Haemaccel (10 ml/kg intravenously over 10-15 minutes) and group C received injection ephedrine (0.2 mg/kg iv) prior to induction of anaesthesia. Propofol (2.5 mg/kg iv) was used for induction of anaesthesia. Heart rate and blood pressure were recorded before induction (baseline) and then every minute for 5 minutes after administering propofol. Anaesthesia was continued with standard technique thereafter. Hypotension was defined as fall in systolic blood pressure more than 20% from the basal value. The incidence of hypotension in Haemaccel (23.1%) or ephedrine group (22.5%) was significantly less than the control group (67.5%, P<0.01). We conclude that though preloading with colloid (Haemaccel) or prior injection of sympathomimetic (ephedrine) are not fully efficacious in preventing hypotension caused by propofol induction, both decrease the incidence in significant number of patients with heart rate less than baseline value in the colloid group.en_US
dc.description.affiliationSiddhartha Children and Women Hospital, AMDA, Butwal, Nepal.en_US
dc.identifier.citationDhungana Y, Bhattarai BK, Bhadani UK, Biswas BK, Tripathi M. Prevention of hypotension during propofol induction: a comparison of preloading with 3.5% polymers of degraded gelatin (Haemaccel) and intravenous ephedrine. Nepal Medical College Journal. 2008 Mar; 10(1): 16-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46934
dc.language.isoengen_US
dc.source.urihttps://www.nmcth.edu/list_journal_articles.phpen_US
dc.source.urihttps://www.nmcth.edu/nmcj_articles_pdf/volume_wise/nmcj_vol10_no1/ydhungana.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnesthetics, Intravenous --adverse effectsen_US
dc.subject.meshEphedrine --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypotension --chemically induceden_US
dc.subject.meshInfusions, Intravenousen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPlasma Substitutes --administration & dosageen_US
dc.subject.meshPolygeline --administration & dosageen_US
dc.subject.meshPropofol --adverse effectsen_US
dc.subject.meshVasoconstrictor Agents --administration & dosageen_US
dc.titlePrevention of hypotension during propofol induction: a comparison of preloading with 3.5% polymers of degraded gelatin (Haemaccel) and intravenous ephedrine.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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