Relapse in psoriasis with two different tapering regimens of methotrexate: A randomized open-label controlled study.

Simple item page
dc.contributor.authorSingh, Satyendra Kumar
dc.contributor.authorRai, Tulika
dc.date.accessioned2015-06-24T05:43:07Z
dc.date.available2015-06-24T05:43:07Z
dc.date.issued2015-03
dc.description.abstractBackground: Systemic therapy with methotrexate is a very useful modality in psoriasis, but relapses can occur soon after stopping it. Aim: To compare the relapse rates in psoriasis with two different tapering regimens of methotrexate after control is achieved. Methods: This was a randomized open-label controlled study, and patients of chronic plaque psoriasis with psoriasis area and severity index (PASI) >10 were included. Methotrexate 0.3 mg/kg weekly was given and the PASI calculated every 2 weeks. After achieving a 75% reduction in the PASI (PASI-75), patients were assigned randomly in to one of three groups. In the half-dose group, the dose of methotrexate was reduced to half and given weekly; in the 2-weekly group, the same dose was given at 2-week intervals; in the control group, methotrexate was stopped. Patients were followed up for 12 weeks. Results: Out of 141 registered patients, 81 were included: 27 in the half-dose group, 28 in the 2-weekly group, and 26 in the control group. After further exclusions due to adverse effects and loss to follow-up, the results were analysed for 16, 17 and 19 patients respectively in the 3 groups. There was statistically a highly signifi cant difference in relapse rates between the half-dose and control groups (P < 0.001), and a signifi cant difference between the 2-weekly and control groups (P = 0.001). Relapse rates in the half-dose and 2-weekly groups did not show a signifi cant difference (P = 0.680). Limitation: Many (35.8%) patients were excluded and only 52 (64.2%) completed the study. Conclusion: There appears to be no signifi cant difference in the frequency of relapse in psoriasis whether methotrexate is tapered by halving the weekly dose or by doubling the interval between two doses, and both methods led to fewer relapses than abrupt cessation of the drug.en_US
dc.identifier.citationSingh Satyendra Kumar, Rai Tulika. Relapse in psoriasis with two different tapering regimens of methotrexate: A randomized open-label controlled study. Indian Journal of Dermatology, Venereology and Leprology. 2015 Mar-Apr; 81(2): 144-147.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158259
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2015;volume=81;issue=2;spage=144;epage=147;aulast=Singhen_US
dc.subjectMethotrexateen_US
dc.subjectPASI-75en_US
dc.subjectpsoriasisen_US
dc.subjectrelapseen_US
dc.subjecttaperingen_US
dc.subject.meshAdult
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshHumans
dc.subject.meshMethotrexate --administration & dosage
dc.subject.meshPsoriasis --drug therapy
dc.subject.meshRandomized Controlled Trials as Topic
dc.subject.meshRecurrence
dc.subject.meshSeverity of Illness Index
dc.titleRelapse in psoriasis with two different tapering regimens of methotrexate: A randomized open-label controlled study.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijdvl2015v81n2p144.pdf
Size:
359.64 KB
Format:
Adobe Portable Document Format
Description:
Original article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Dermatology, Venereology and Leprology