Effect of chinese traditional herb Epimedium grandiflorum C.Morren and its extract Icariin on osteoarthritis via suppressing NF-kB pathway.

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dc.contributor.authorWenliang, Zhang
dc.contributor.authorRongheng, Li
dc.contributor.authorShumei, Wang
dc.contributor.authorFangzheng, Mu
dc.contributor.authorPing, Jia
dc.date.accessioned2013-07-31T04:15:18Z
dc.date.available2013-07-31T04:15:18Z
dc.date.issued2013-04
dc.description.abstractOsteoarthritis (OA), which is also called degenerative arthritis, is the leading cause of disabilities in the old people. The Chinese traditional herb Epimedium grandiflorum had long been found to attenuate osteoarthritis process, but the detailed mechanism was not clear. To study the mechanisms of E. grandiflorum in the treatment of osteoarthritis, rabbit osteoarthritis model combined with D-galactose was used. After different treatments for 10 weeks, cartilage sections were analyzed by immunohistochemistry for uPA, uPAR and PAI expression level. E. grandiflorum could significantly attenuate OA condition and decrease uPA, uPAR and PAI expression. The extract of E. grandiflorum, icariin also had a similar effect when compared with E. grandiflorum treatment alone. Rabbit chondrocytes were further isolated to be stimulated by TNFα combined with different reagents treatment. Here, icariin treatment significantly reduced nuclear factor kappa B NF-B (P65) activity, decreased uPA expression level and increased IBα protein level. The results indicated that E. grandiflorum and its extract icariin could attenuate OA condition, reduce the expression of uPA and uPAR and increase PAI in experimental rabbit model and this effect may be conducted by suppressing NF-kB activity by increasing IkBα level.en_US
dc.identifier.citationWenliang Zhang, Rongheng Li, Shumei Wang, Fangzheng Mu, Ping Jia. Effect of chinese traditional herb Epimedium grandiflorum C.Morren and its extract Icariin on osteoarthritis via suppressing NF-kB pathway. Indian Journal of Experimental Biology. 2013 Apr; 51(4): 313-321.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147597
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/16550en_US
dc.subjectEpimedium grandiflorumen_US
dc.subjectIcariinen_US
dc.subjectOsteoarthritisen_US
dc.subjectNF-kB (P65)en_US
dc.subjectuPAen_US
dc.subject.meshAnimals
dc.subject.meshCartilage --metabolism
dc.subject.meshChondrocytes --cytology
dc.subject.meshDisease Models, Animal
dc.subject.meshDrugs, Chinese Herbal --therapeutic use
dc.subject.meshEpimedium --metabolism
dc.subject.meshFemale
dc.subject.meshFlavonoids --therapeutic use
dc.subject.meshGalactose --metabolism
dc.subject.meshI-kappa B Proteins --metabolism
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMedicine, Chinese Traditional
dc.subject.meshNF-kappa B --antagonists & inhibitors
dc.subject.meshNF-kappa B --metabolism
dc.subject.meshOsteoarthritis --drug therapy
dc.subject.meshPlasminogen Activator Inhibitor 1 --metabolism
dc.subject.meshRabbits
dc.subject.meshReceptors, Urokinase Plasminogen Activator --metabolism
dc.subject.meshTumor Necrosis Factor-alpha --metabolism
dc.subject.meshUrokinase-Type Plasminogen Activator --metabolism
dc.titleEffect of chinese traditional herb Epimedium grandiflorum C.Morren and its extract Icariin on osteoarthritis via suppressing NF-kB pathway.en_US
dc.typeArticleen_US
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