Effects of long-acting steroid contraceptives on ovarian and uterine histology of rats.

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Date
1977-06-01
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Abstract
Subcutaneous injection of single doses (5 to 20 mg/kg) of DMPA or NE in virgin female rats caused reduction in number and diameter of CL, and increase in number of atretic and cystic follicles in the ovary. Histological examination of the endometrium of these animals showed low cubiodal cells with sparse distribution of low columnar cells, glands with atrophic changes and compact uterine stroma with or without patches of oedema. The results suggest regressive and atrophic changes in the ovary and endometrium.
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Bangladesh Medical Research Council Bulletin.
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Harun-Ar-Rashid , Bari MA, Choudhury SA. Effects of long-acting steroid contraceptives on ovarian and uterine histology of rats. Bangladesh Medical Research Council Bulletin. 1977 Jun; 3(1): 46-51