Rapid immunodiagnosis of active cytomegalovirus infection by pp65 antigenemia assay.
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2006-04-02
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Abstract
Detection of early antigen PP65 in blood leucocytes is a new method of diagnosing active cytomegalovirus (CMV) infection. Using a mixture of two monoclonal antibodies, CMV pp65 antigen was detected in blood leucocytes by a quantitative indirect immunofluorescence test within 3-5 hours after sampling. The pp65 antigen was detected in 20(29.8%) of the 67 immunocompromised patients included in this study. The level of CMV antigenemia appears to be related to the severity of CMV infection. Thus, this method may provide a rapid and sensitive approach to early diagnosis of active CMV infection in immunocompromised patients and a promising marker for initiating therapy and monitoring disease activity and its response to therapy.
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Bangladesh Medical Research Council Bulletin.
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Jahan M, Tabassum S, Islam MN. Rapid immunodiagnosis of active cytomegalovirus infection by pp65 antigenemia assay. Bangladesh Medical Research Council Bulletin. 2006 Apr; 32(1): 22-8