Amlodipine in mild and moderate hypertension: initial Indian experience.
No Thumbnail Available
Date
1993-10-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In an open, non-comparative, variable-dose study, 20 outpatients with mild to moderate essential hypertension were treated with 5-10 mg amlodipine once daily for 4 weeks, after their blood pressures had stabilized on placebo. Amlodipine produced a significant decrease in blood pressure (P < 0.05) from the initial mean of 162/100 mm Hg to 139/85 mm Hg at 4 weeks. 80% of the patients reached the goal diastolic blood pressure of < or = 90 mm Hg with a once-daily dose of 5 mg amlodipine within 2 weeks. The remaining 20% also attained the goal diastolic blood pressure within 4 weeks, with a one-step increase in the dose to 10 mg at 2 weeks. Amlodipine maintained blood pressure reduction throughout the 24-hours dosing interval with a once-daily dose. Notably, no side effects were observed; pulse rate, electrocardiogram, and laboratory parameters were not significantly altered with therapy. Amlodipine in a single daily dose of 5-10 mg is effective and well tolerated in the treatment of patients with mild to moderate hypertension.
Description
Keywords
Citation
Khokhani RC, Chopra P, Karnik ND, Bajan KD, Ailiani R, Waknis SS, Joseph TA, Chawla KP. Amlodipine in mild and moderate hypertension: initial Indian experience. Journal of the Association of Physicians of India. 1993 Oct; 41(10): 662-3