An open clinical trial of benazepril--a new ACE inhibitor in mild-moderate hypertension.
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1998-03-29
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Benazepril hydrochloride, a new non-sulfhydryl ACE inhibitor (ACEI) was studied in a titrated dose of 10 mg-20 mg once a day for 6 weeks in 42 mild to moderate adult hypertensive patients with sitting diastolic blood pressure (SDBP) 95-114 mm Hg. The pre-drug SDBP(mean +/- SE) of 102.5 +/- 0.8 mm Hg showed a significant reduction to 87.5 +/- 0.93 mm Hg at the end of treatment. BP was controlled (SDBP < or = 90 mm Hg) in 34 (81%) patients and a drop of at least 10 mm Hg from the pre-treatment SDBP value was noted in 34 (81%) patients. Common adverse reaction was cough in 8(19%) patients. Clinically significant changes in laboratory evaluations were not seen in any patient. Study showed that benazepril in a dose range of 10 to 20 mg per day is an effective agent for treatment of mild to moderate hypertension.
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Karnik ND, Oza YK, Sane SP, Kaushik R, Bhatt AD, Chawla KP, Vaidya AB, Yajnik VH, Khokhani RC. An open clinical trial of benazepril--a new ACE inhibitor in mild-moderate hypertension. Journal of the Association of Physicians of India. 1998 Mar; 46(3): 283-5