Effect of calcium channel antagonists on cholinergic bronchial responsiveness in asthma.

No Thumbnail Available
Date
1993-05-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Bronchial responsiveness to methacholine was studied in 23 stable asthmatics before and after nifedipine and diltiazem. There was no significant bronchodilatory effect of either calcium channel antagonists. The mean provocative dose of methacholine required to produce a 20% fall in FEV1 (PC20 = 0.157 +/- 0.74 mg) was not altered by nifedipine (PC20 = 0.159 +/- 0.61). However, diltiazem offered significant protection. The mean ratio of PC20 after diltiazem over baseline was 3.27 +/- 3.55. The results suggest that although both calcium channel antagonists have no influence on normal basal bronchomotor tone, diltiazem does significantly protect against cholinergic stimulation.
Description
Keywords
Citation
Talwar D, Jindal SK. Effect of calcium channel antagonists on cholinergic bronchial responsiveness in asthma. Journal of the Association of Physicians of India. 1993 May; 41(5): 279-80
URI
https://imsear.searo.who.int/handle/123456789/88710
Collections
Journal of the Association of Physicians of India