A clinico-haematologic profile of paroxysmal nocturnal haemoglobinuria.

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1991-10-01
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Abstract
Clinico-haematological parameters in sixteen patients of paroxysmal nocturnal haemoglobinuria (PNH) are presented. Their modes of presentation included recurrent episodes of cola-coloured urine (6/16), refractory anaemia (9/16) and predominant thrombotic manifestations (1/16). Laboratory investigations revealed the presence of anaemia (16/16), reticulocytosis (14/16), thrombocytopenia (11/16), leucopenia (5/16) and cellular bone marrow (14/16). Two patients had hypoplastic bone marrow initially but subsequently developed PNH. The patients were treated with haematinics, prednisolone (16/16) and oxymethalone (2). Prednisone was effective in suppressing haemolytic episodes. Oxymethalone given to the 2 patients with hypoplastic bone marrow resulted in amelioration of anaemia in one but no effect in the other patient.
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Saxena R, Malhotra OP, Saraya AK. A clinico-haematologic profile of paroxysmal nocturnal haemoglobinuria. Journal of the Association of Physicians of India. 1991 Oct; 39(10): 741-3
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https://imsear.searo.who.int/handle/123456789/87026
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Journal of the Association of Physicians of India