Serum immunoglobulins, IgG subclasses, isohemagglutinins and complement-3 levels in patients with thalassemia major.

Vergin, C; Kutukculer, N; Cetingul, N; Nisli, G; Caglayan, S; Oztop, S

Serum immunoglobulins, IgG subclasses, isohemagglutinins and complement-3 levels in patients with thalassemia major.

Date

1997-03-01

Authors

Abstract

Serum IgG, IgM, IgA, IgG subclasses (IgG1, G2, G3, G4), isohemagglutinins and complement-3 concentrations were measured in 23 beta-thalassemic patients suffering from recurrent infections. No significant abnormalities were found in these humoral immunity investigations, both in splenectomized and non-splenectomized patients. On the other hand, iron overload or repeated blood transfusions were not found to down-regulate the humoral immune system of thalassemic patients.

Citation

Vergin C, Kutukculer N, Cetingul N, Nisli G, Caglayan S, Oztop S. Serum immunoglobulins, IgG subclasses, isohemagglutinins and complement-3 levels in patients with thalassemia major. Indian Journal of Pediatrics. 1997 Mar-Apr; 64(2): 215-9