Chronic lung disease in newborns.
No Thumbnail Available
Date
2008-04-24
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Chronic lung disease (CLD) or bronchopulmonary dysplasia (BPD) occurs in preterm infants who require respiratory support in the first few days of birth. Apart from prematurity, oxygen therapy and assisted ventilation, factors like intrauterine/postnatal infections, patent ductus arteriosus, and genetic polymorphisms also contribute to its pathogenesis. The severe form of BPD with extensive inflammatory changes is rarely seen nowadays; instead, a milder form characterized by decreased alveolar septation due to arrest in lung development is more common. A multitude of strategies, mainly pharmacological and ventilatory, have been employed for prevention and treatment of BPD. Unfortunately, most of them have not been proved to be beneficial. A comprehensive protocol for management of BPD based on the current evidence is discussed here.
Description
45 references.
Keywords
Citation
Sankar MJ, Agarwal R, Deorari AK, Paul VK. Chronic lung disease in newborns. Indian Journal of Pediatrics. 2008 Apr; 75(4): 369-76