Myxomatous stromal changes and necrosis of bone marrow--a retrospective study of 3 years.
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Date
2004-07-22
Authors
Gupta, Nalini
Kumar, Vijay
Varma, Neelam
Garewal, Gurjeevan
Das, Reena
Ahluwalia, Jasmina
Dash, Sumitra
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Abstract
Myxomatous stromal changes and bone marrow necrosis (BMN) are uncommon histologic findings. These changes have been found in various conditions like disseminated carcinomatosis, postchemotherapy cases, chronic infections, infiltrative disorders of the marrow etc. The present study is a retrospective study of 3 years (Jan, 1999 to Dec. 2001) from Deptt. Of Hematology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh (India). During this period, 3740 bone marrow samples were examined. Myxomatous stromal changes and bone marrow necrosis were noted in 0.43% (16/3740) and 0.45% (17/3740) samples respectively. In addition to common causes of myxomatous stromal changes and bone marrow necrosis as described in the literature, this study highlights the association of these conditions with some of the rarer entities like hyperoxalosis, leishmaniasis, parvovirus induced marrow aplasia and cryptococcal infection. There is paucity of such associations in the literature.
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Gupta N, Kumar V, Varma N, Garewal G, Das R, Ahluwalia J, Dash S. Myxomatous stromal changes and necrosis of bone marrow--a retrospective study of 3 years. Indian Journal of Pathology & Microbiology. 2004 Jul; 47(3): 351-3