Reed-Sternberg-like cells in T-cell rich B-cell lymphoma: a diagnostic dilemma.

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2003-01-19
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T-cell-rich B-cell lymphoma (TCRBCL) is a recently described variant of diffuse Non-Hodgkin's lymphoma (NHL) which requires immunohistochemical analysis for its recognition. Striking similarities exist between TCRBCL and lymphocyte predominant Hodgkin's Disease (LPHD) due to the presence of Reed-Sternberg (R-S) like cells. Hence, the need for distinction between the two is of utmost importance from a prognostic and therapeutic stand point. The present study describes a case of TCRBCL, misdiagnosed as Hodgkin's Disease (HD) on fine needle aspiration (FNA) cytology. However, immunostaining of paraffin embedded sections corrected the cytological diagnosis.
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Shahabuddin MD, Raghuveer CV. Reed-Sternberg-like cells in T-cell rich B-cell lymphoma: a diagnostic dilemma. Indian Journal of Pathology & Microbiology. 2003 Jan; 46(1): 55-6