Evaluation of iron status: zinc protoporphyrin vis-a-vis bone marrow iron stores.
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2008-01-18
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Abstract
Zinc protoporphyrin (ZPP) in the red cells is an indicator of iron status in the bone marrow (BM) and can be easily measured by Protofluor-Z Hematofluorometer from Helena Laboratories. It is well known that bone marrow iron is a gold standard for the diagnosis of iron deficiency anemia (IDA) even in the pre-latent phase. Hence, it was considered pertinent to evaluate the diagnostic utility of ZPP in comparison with bone marrow iron stores. 107 random BM were selected over a period of 2(1/2) years; in each case, RBC indices where recorded along with ZPP and Perls' Prussian blue reaction for BM iron stores. The specificity and sensitivity were found to be 77.8% and sensitivity 69.8%, respectively. However, the sensitivity increased up to 96.2% when Hb, RBC indices and ZPP were considered for the diagnosis of IDA.
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Das S, Philip KJ. Evaluation of iron status: zinc protoporphyrin vis-a-vis bone marrow iron stores. Indian Journal of Pathology & Microbiology. 2008 Jan-Mar; 51(1): 105-7