Nerve cell markers in ossifying fibromyxoid tumour of soft parts.

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Date
2001-04-09
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Abstract
Reported herein are two benign ossifying fibromyxoid tumors (OFMTs) of the soft tissues in axilla and terminal phalanx respectively. Both cases on immunohistochemistry (IHC) showed reactivity for vimentin, S-100 protein and glial fibrillary acidic protein (GFAP) antibodies. In addition, a focal/diffuse strong positivity for neurofilament (NF) and neuron specific enolase (NSE) was observed. Electron microscopy in one instance revealed abundant intermediate filaments, primitive cell junctions and a focally present external lamina. In the light of nerve cell differentiation of these tumors and the similarity of IHC profile and EM features of OFMT to a poorly differentiated malignant peripheral nerve sheath tumor (MPNST); it is suggested that OFMT is a variably differentiated PNST rather than a simple Schwannian neoplasm as is believed.
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Shet T, Desai S, Kane S, Vora I. Nerve cell markers in ossifying fibromyxoid tumour of soft parts. Indian Journal of Pathology & Microbiology. 2001 Apr; 44(2): 163-7
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https://imsear.searo.who.int/handle/123456789/74265
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Indian Journal of Pathology & Microbiology