Alpha-1 antitrypsin deficiency among Indian children with liver disorders.

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Date
2006-07-16
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Abstract
AIMS: To determine the frequency of alpha-1 antitrypsin (AAT) deficiency in children with chronic liver disease (CLD) and neonatal cholestasis syndrome (NCS). METHODS: All children with NCS (n=23) or CLD (n=35) attending the Pediatric Gastroenterology Clinic between November 2003 and July 2005 were screened for AAT deficiency using phenotyping through isoelectric focusing of plasma. RESULTS: Of the 58 children studied, 57 had normal PiMM phenotype. One child with CLD had the M1E type of normal variant. None of the patients had the abnormal phenotype PiZZ. CONCLUSION: AAT deficiency is infrequent among children with CLD and NCS in our region.
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Khanna R, Alam S, Sherwani R, Arora S, Arora NK, Malik A. Alpha-1 antitrypsin deficiency among Indian children with liver disorders. Indian Journal of Gastroenterology. 2006 Jul-Aug; 25(4): 191-3
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https://imsear.searo.who.int/handle/123456789/65050
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Indian Journal of Gastroenterology