Liver function and plasma protein metabolism in rodent model of filariasis.
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1989-07-01
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Abstract
Rodent model of filariasis was developed by infecting Wistar rats with Litomosoides carinii. Liver function tests, plasma protein concentrations, and synthesis rates of liver-formed proteins were estimated in these rats at 63 and 90 days post-infection. At 63 days post-infection, aspartate aminotransferase and alkaline phosphatase were significantly increased. Alanine aminotransferase, plasma total proteins and plasma albumin were in the normal range. However, at 90 days post-infection all these parameters were affected, reflecting progressive liver involvement. Hypoalbuminemia at 90 days post-infection did not appear to be due to decreased synthesis rate, indicating higher catabolism and/or altered distribution in pools.
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Nadkarni GD, Deshpande UR, Bhopale MK. Liver function and plasma protein metabolism in rodent model of filariasis. Indian Journal of Gastroenterology. 1989 Jul; 8(3): 151-3