Platelet serotonin uptake in duodenal ulcer patients.
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1994-04-01
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Abstract
Platelet serotonin uptake was measured in 10 duodenal ulcer patients and 10 controls by determining the concentration of radioactivity in platelets after incubation with tritium-labelled serotonin binoxalate. Platelet 5-HT uptake in ulcer patients (312.0 +/- 125.0 CPM/10(7) platelets) was significantly higher than that in the control group (186.0 +/- 53.0 CPM/10(7) platelets; p < 0.01). Since the kinetics of 5-HT uptake by platelets may be a reflector of enhanced serotonergic activity, this finding may have implications in future therapeutic strategies for this disease.
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Misra R, Komandur R, Chandra M, Shankar K, Zaheer SM, Ram S, Gujrati VR. Platelet serotonin uptake in duodenal ulcer patients. Indian Journal of Gastroenterology. 1994 Apr; 13(2): 54-5