Anti-secretagogue effect of lithium on isolated rat islets of Langerhans.
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1989-02-01
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Abstract
Administration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.
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Chandrasekar B, Mathur SK, Mukherjee SK. Anti-secretagogue effect of lithium on isolated rat islets of Langerhans. Indian Journal of Experimental Biology. 1989 Feb; 27(2): 163-5