Radioprotective efficacy of HT + AET in encapsulated form.

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Date
1996-05-01
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Abstract
Entrapment of 5-hydroxyl-L-tryptophan (HT) in erythrocyte ghost prepared by hypotonic method and high voltage electric discharge method are nearly same. Release of HT with beta-aminoethylisothiuronium bromide hydrobromide (HT + AET) in in vitro system is rapid but only a portion of the entrapped amount is released. Release of HT + AET in serum marginally increases at 2 hr. Compared to release in in vitro medium the release in serum is less. Survival studies with Swiss albino mice indicates that compared to HT alone, the combination of HT + AET shows about 9 times percentage survival. The same combination in the encapsulated form show comparable percentage survival though the amount needed is 1/200th times compared to free form.
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Upadhyay SN, Dey TB, Ghose A. Radioprotective efficacy of HT + AET in encapsulated form. Indian Journal of Experimental Biology. 1996 May; 34(5): 403-7
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https://imsear.searo.who.int/handle/123456789/62888
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Indian Journal of Experimental Biology