Immunotoxicity of soluble and insoluble salts of cadmium instilled intratracheally.
No Thumbnail Available
Date
2002-03-15
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Rats were intratracheally (i.t.) exposed to 36.5 or 27.5 microg of cadmium (Cd) as soluble cadmium chloride (CdCl2) and insoluble cadmium oxide (CdO) salts. The retention of metal in lungs, liver and kidney was assessed by atomic adsorption spectrophotometer. The animals were intraperitoneally (i.p.) primed with sheep red blood cells (SRBC) and assessed for the number of antibody forming cells in lung associated lymph nodes (LALN) and spleen. Both the compounds had similar retention of metal in lungs but CdO induced more pulmonary inflammatory and degradative changes than CdCl2. The larger influx of polymorphonuclear cells (PMNs) following CdO exposure appears to be due to the absence of protection afforded by Cd induced metallothionein cytoplasmic protein while the Cd metallothionein complex formed in the case of CdCl2 is more protective. However both forms of Cd had similar local immunosuppressive potential but CdO had more prolonged suppressive effect.
Description
Keywords
Citation
Dogra S, Waseem M, Khanna AK, Kaw JL. Immunotoxicity of soluble and insoluble salts of cadmium instilled intratracheally. Indian Journal of Experimental Biology. 2002 Mar; 40(3): 262-7