Antimutagenic effects of polyphenols isolated from Terminalia bellerica myroblan in Salmonella typhimurium.
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1996-02-01
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Antimutagenic effect of 2 polyphenolic fractions isolated from T. bellerica in TA98 and TA100 strains of S. typhimurium against 2AF, NPD and 4NQNO has been characterized. Both the fractions were significantly effective against S9-dependent 2AF; less effective against NPD and almost not effective against 4NQNO in TA100 strain. Using 13C-NMR spectral analysis, the TB-3 fraction, which was significantly more effective against 2AF compared to TB-4, was found to be a mixture of 3 tannins while TB-4 was non-tannin fraction. Interaction of polyphenols with S9 proteins may be the probable cause of inhibitory effect of these polyphenols, though the possibility of other mechanisms cannot be ruled out.
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Padam SK, Grover IS, Singh M. Antimutagenic effects of polyphenols isolated from Terminalia bellerica myroblan in Salmonella typhimurium. Indian Journal of Experimental Biology. 1996 Feb; 34(2): 98-102