Alterations of phosphatidylinositol signal transduction pathway in hepatic mitochondria following aflatoxin B1 administration.
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1999-09-25
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A single dose of aflatoxin B1 (7 mg/kg body wt) to male rats significantly stimulated the turnover of mitochondrial phosphoinositides 1-7 hr following its administration. The elevation of phosphatidylinositol 3,4,5-trisphosphate was most pronounced whose level continued to be moderately high even at 17 hr period. The level of diacylglycerol showed a marked increase from 4 hr till 7 hr after carcinogen treatment, whereas that of inositol 1,4,5-trisphosphate recorded an increase with a maximum at 7 hr followed by a gradual decrease to near normal level at 24 hr period. The activation of phosphatidylinositol cycle together with an activation of PI 3-kinase, whose product PIP3 is known to be involved in apoptosis might contribute to the early step in the manifestation of toxicity and/or carcinogenicity.
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Pasupathy K, Krishna M, Bhattacharya RK. Alterations of phosphatidylinositol signal transduction pathway in hepatic mitochondria following aflatoxin B1 administration. Indian Journal of Experimental Biology. 1999 Sep; 37(9): 876-80