Lectin mediated binding of Streptococcus pyogenes to human oropharyngeal mucosal epithelial cells.

No Thumbnail Available
Date
1996-03-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The study was carried out to determine the role of lectins and sugars in the adhesion of S. pyogenes to human pharyngeal and buccal epithelial cells. In vitro adhesion assay has shown that Con A and Dolicos biflorus lectins inhibited the attachment of S. pyogenes to the oropharyngeal mucosal cells. Among different sugars used, N-acetyl-D-galactosamine and D-galactose have significantly blocked the binding of streptococci to PEC and BEC. These findings indicate that lectins and sugar molecules mediate the adhesion of S. pyogenes to the pharyngeal epithelial cells which may be important in the cellular pathogenesis of streptococcal infections which originate at the human oropharyngeal mucosa.
Description
Keywords
Citation
Kumar KS, Ganguly NK, Anand IS, Wahi PL. Lectin mediated binding of Streptococcus pyogenes to human oropharyngeal mucosal epithelial cells. Indian Journal of Experimental Biology. 1996 Mar; 34(3): 270-1
URI
https://imsear.searo.who.int/handle/123456789/61523
Collections
Indian Journal of Experimental Biology