Evaluation of vanillic acid analogues as a new class of antifilarial agents.

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1993-10-01
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Abstract
A number of vanillic acid analogues (1-14) have been synthesised and evaluated against experimental filarial infections using cotton rats (Sigmodon hispidus) infected with Litomosoides carinii, a primary screening model, at a dose of 30 mg/kg, ip for 5 days. Of the 8 compounds tested, 4 (5,7, 11 and 12) exhibited high micro- and macro-filaricidal activity with sterilization of surviving female worms. Compounds 5, 7, 12 showed remarkable adulticidal action (> 80%). Sterilization of the female worms by compounds 11 and 12 was highly significant (80-100%).
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Varma RS, Shukla A, Chatterjee RK. Evaluation of vanillic acid analogues as a new class of antifilarial agents. Indian Journal of Experimental Biology. 1993 Oct; 31(10): 819-21
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https://imsear.searo.who.int/handle/123456789/61329
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Indian Journal of Experimental Biology