Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in PVC blood storage bags.

Dhanya, C R; Gayathri, N S; Mithra, K; Nair, K V Neelakantan; Kurup, P A

Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in PVC blood storage bags.

Date

2004-09-07

Authors

Dhanya, C R

Gayathri, N S

Mithra, K

Nair, K V Neelakantan

Kurup, P A

Abstract

Vitamin E administration prevented DEHP induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane Na+ - K+ ATPase, (iii) decrease in the concentration of insulin, cortisol and TSH, and (iv) the increase in T3 and T4 in female Albino rats. The results suggest use of vitamin E to prevent harmful effects of repeated transfusion of DEHP containing blood as in thalassemia patient. The possibility of using vitamin E to prevent the harmful effects of repeated transfusion of DEHP containing blood, as in thalassemia patients, is discussed.

Citation

Dhanya CR, Gayathri NS, Mithra K, Nair KV, Kurup PA. Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in PVC blood storage bags. Indian Journal of Experimental Biology. 2004 Sep; 42(9): 871-5