Effect of alpha,beta-arteether against primary amoebic meningoencephalitis in Swiss mice.
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1998-08-05
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Abstract
Artemisinin and its derivative alpha, beta-arteether have been evaluated for activity against experimental primary amoebic meningoencephalitis. In vivo experiments have shown that amphotericin B at dose of 2.5 mg/kg for 5 days produced 100% protection. Artemisinin and alpha, beta-arteether, even when tested at a high doses (60-120 mg/kg x 5 days and 90-180 mg/x 5 days) respectively, were not curative and showed only slight protection as indicated by extension of mean survival time.
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Gupta S, Dutta GP, Vishwakarma RA. Effect of alpha,beta-arteether against primary amoebic meningoencephalitis in Swiss mice. Indian Journal of Experimental Biology. 1998 Aug; 36(8): 824-5