Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV.
No Thumbnail Available
Date
2008-01-14
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Immunostimulatory activity of AC II, a registered ayurvedic preparation prepared at Amala Ayurvedic Research Centre for treating HIV and AIDS is reported. AC II administration could significantly enhance the mitogen-induced proliferation of lymphocytes of spleen cells. It was also found to increase cell-mediated immune responses in normal and tumor-bearing control animals. Oral administration of AC II significantly enhanced Natural Killer cell activity in normal and tumor-bearing animals on the 7th day, which was observed earlier than the tumor-bearing control animals and normal animals. Antibody dependent cellular cytotoxicity (ADCC) was also increased in AC II treated normal and tumor-bearing animals. An early enhancement of antibody-dependent complement-mediated cytotoxicity was also observed by the administration of AC II in normal as well as tumor-bearing animals. Treatment with AC II elevated the levels of IL-2, TNF-alpha and IFN-gamma in normal mice. Administration of AC II was also found to increase the cytotoxic T lymphocyte production in EL4 treated mice. These studies support the use of this immune stimulatory preparation in HIV patients.
Description
Keywords
Citation
Tharakan ST, Kuttan G, Kuttan R, Kesavan M, Austin , Rajagopalan K. Immunostimulatory action of AC II--an ayurvedic formulation useful in HIV. Indian Journal of Experimental Biology. 2008 Jan; 46(1): 47-51