Identification and characterization of receptor for dengue virus-induced macrophage cytotoxin.
No Thumbnail Available
Date
1996-07-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to that causing cell death. Scatchard analysis showed the presence of intermediate type of affinity receptor and the number of receptor sites was 1.1 x 10(6) per cell with dissociation constant of 14.28 nM.
Description
Keywords
Citation
Khare PD, Dhawan R, Chaturvedi UC. Identification and characterization of receptor for dengue virus-induced macrophage cytotoxin. Indian Journal of Experimental Biology. 1996 Jul; 34(7): 652-7