Production of cephalosporin C by immobilized cells of Cephalosporium acremonium.
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2000-11-09
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Abstract
Cephalosporium acremonium ATCC 48272 cells were immobilized on various adsorbents and in various entrapment matrices. The influence of the incubation period, the best immobilization technique and the optimum concentrations of the selected matrices were investigated. From the results of the repeated batch fermentation in shake flasks, a good level of antibiotic was maintained for a period of about 19 days using 4% calcium alginate and 1% glass wool as entrapment and adsorbent supports, respectively.
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Ellaiah P, Murali Chand G, Srinivasulu B, Pardhasaradhi SV. Production of cephalosporin C by immobilized cells of Cephalosporium acremonium. Indian Journal of Experimental Biology. 2000 Nov; 38(11): 1134-7