Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice.

No Thumbnail Available
Date
2007-07-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
Description
Keywords
Citation
Gilhotra N, Sharma A, Singh M. Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice. Indian Journal of Experimental Biology. 2007 Jul; 45(7): 654-6
URI
https://imsear.searo.who.int/handle/123456789/59884
Collections
Indian Journal of Experimental Biology