Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats.
No Thumbnail Available
Date
1989-07-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Central effects of naloxone on the cardiovascular responses of centrally administered clonidine were studied in anaesthetised normotensive, renal DOCA-salt hypertensive and morphine dependent rats. Clonidine (5 micrograms/ICV) produced significant decrease in blood pressure and heart rate in all the groups of rats in a dose dependent manner. Naloxone (2 micrograms/ICV) failed to reverse the responses of clonidine in all the rat groups. In morphine dependent normotensive and morphine dependent renal DOCA-salt hypertensive rats, the responses of clonidine were further enhanced in the presence of naloxone. Our observations clearly indicate that clonidine does not influence endogenous opioid system for producing cardiovascular effects.
Description
Keywords
Citation
Srivastava RK, Kaur AH. Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats. Indian Journal of Experimental Biology. 1989 Jul; 27(7): 628-30