Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy.
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2006-12-21
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Transcranial magnetic stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold intensity to male WAG/Rij rats. One group received stimuli, which involved motor responses of hindlimbs, rats of the second group received sham stimulation. Electrocorticograms (ECoG) were recorded before and up to 2 hr from the moment of transcranial magnetic stimulation. It was established that such stimulation engendered a reduction of spike-wave discharge (SWD) bursts duration. This effect was most pronounced in 30 min from the moment of cessation of stimulation, when a decrease of 31.4% was noted in comparison with sham-stimulated control group. The number of bursts of spike-wave discharges was reduced, but did not reach significant difference when compared both with pre-stimulative base-line level and with sham-stimulated control rats. Bursts of spike-wave discharges restored up to pre-stimulative level in 90-150 minutes from the moment of cessation of transcranial stimulation. It can be concluded that transcranical magnetic stimulation possessed an ability to engender short-time suppression of bursts of spike-wave discharges in WAG/Rij rats.
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Godlevsky LS, Kobolev EV, van Luijtelaar EL, Coenen AM, Stepanenko KI, Smirnov IV. Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy. Indian Journal of Experimental Biology. 2006 Dec; 44(12): 949-54