Immunoexpression of mutant p53 and human papillomavirus related E6 oncoprotein in anal malignancies.
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1998-09-17
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Immunohistochemical expression of mutant p53 protein and human papillomavirus (HPV) 16 and 18 related E6 oncoprotein was studied in 36 biopsy proved anal cancers. Mutant p53 was detected in 61.1% cases. HPV 16 and 18 E6 protein was expressed in 22.2% cases, all of which were squamous cell carcinomas. Coexpression of both mutant p53 and E6 protein was found in only 5 cases (13.8%). In HPV 16/18 positive anal tumors, the degradation of p53 is accelerated by viral E6 oncoprotein. In HPV negative tumors, however, other mutagenic factors probably play a role in carcinogenesis.
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Gupta S, Sharma BK. Immunoexpression of mutant p53 and human papillomavirus related E6 oncoprotein in anal malignancies. Indian Journal of Experimental Biology. 1998 Sep; 36(9): 875-8