Effects of cisplatin on testicular functions in rats.
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1996-10-01
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In adult male rats serum levels of FSH, LH and testosterone were determined following treatment with cisplatin [cis-diamminedichloroplatinum(II)] for 3 alternate days, in order to study the effects of cisplatin on pituitary-testicular axis and subsequent effects on spermatogenesis. The decreased levels of testosterone with elevated FSH and LH levels in CDDP-treated rats are indicative of intact pituitary-testicular axis. The quantitation of spermatogenesis by flow cytometric analysis revealed that various germ cell populations and kinetics of spermatogenesis remain unchanged in CDDP-treated rats. Thus, CDDP treatment has been shown to decrease testosterone production in the testis without affecting the functional status of spermatogenic compartment.
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Malarvizhi D, Mathur PP. Effects of cisplatin on testicular functions in rats. Indian Journal of Experimental Biology. 1996 Oct; 34(10): 995-8