Swerchirin induced blood sugar lowering of streptozotocin treated hyperglycemic rats.
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1991-07-01
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Abstract
Effect of Swerchirin (1:8 dihydroxy 3:5 dimethoxy xanthone) isolated from hexane fraction of Swertia chirayita on the blood sugar level of healthy and streptozotocin treated rats was studied. Streptozotocin was administered in citrate buffer (pH-4.5) intravenously / 35 and 65 mg/kg body wt to Charles Foster strain albino rats. Swerchirin (50 mg/kg, po) suspended in gum acacia was fed through cannula to the above rats and to a group of healthy rats. Blood sugar estimated at 0, 1, 3 and 7 hr after, indicated a very significant lowering in healthy and streptozotocin (35 mg/kg iv) but not in streptozotocin (65 mg/kg) treated rats.
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Saxena AM, Bajpai MB, Mukherjee SK. Swerchirin induced blood sugar lowering of streptozotocin treated hyperglycemic rats. Indian Journal of Experimental Biology. 1991 Jul; 29(7): 674-5