Suppression of Con A induced lymphocyte transformation by sera from filarial patients with clinical manifestations.
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1991-04-01
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Abstract
Reduced lymphocyte transformation to Wuchereria bancrofti microfilariae excretory-secretory antigen and Con A were observed in clinical filarial patients. Pre-incubation of normal human peripheral blood mononuclear cells with sera from filarial patients with clinical manifestations such as hydrocele and elephantiasis suppressed Con A induced responses. Effect of fractionated clinical filarial serum on Con A induced lymphocyte transformation showed that the inhibitory activity was associated with high molecular weight serum fraction.
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Prasad GB, Kharat I, Harinath BC. Suppression of Con A induced lymphocyte transformation by sera from filarial patients with clinical manifestations. Indian Journal of Experimental Biology. 1991 Apr; 29(4): 352-4