Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.

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Date
1990-12-01
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Abstract
Liver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in aspartate and glutamate pretreated animals as observed macroscopically and histologically.
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Singh J, Garg KN, Mehrotra GC. Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats. Indian Journal of Experimental Biology. 1990 Dec; 28(12): 1180-3
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https://imsear.searo.who.int/handle/123456789/57274
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Indian Journal of Experimental Biology