Effect of sub-chronic endosulfan exposures on plasma gonadotrophins, testosterone, testicular testosterone and enzymes of androgen biosynthesis in rat.
No Thumbnail Available
Date
1990-10-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Insecticide endosulfan significantly inhibited testicular androgen biosynthesis in adult rats, when fed (po) at 7.5 and 10 mg/kg body weight dose levels, consecutively for 15 and 30 days. No appreciable alterations were apparent in body weights, testicular wet weights, and cytosolic and microsomal protein contents of testis in treated rats. Profound decrease in the levels of plasma gonadotrophins (FSH and LH) along with plasma testosterone and testicular testosterone were observed at both the doses of endosulfan, particularly after the longer exposure of 30 days. Activities of steroidogenic enzymes studied (3 beta- and 17 beta-hydroxysteroid dehydrogenases) were considerably lowered on longer exposure of endosulfan. A significant decrease in the contents/activities of microsomal cytochrome P-450 and related mixed function oxidases (MFOs) in testis of treated rats was also observed, along with a marked inhibition in the activity of cytosolic conjugation enzyme, glutathione-S-transferase at both doses studied. These biochemical changes were reversed when the endosulfan treatment was withdrawn.
Description
Keywords
Citation
Singh SK, Pandey RS. Effect of sub-chronic endosulfan exposures on plasma gonadotrophins, testosterone, testicular testosterone and enzymes of androgen biosynthesis in rat. Indian Journal of Experimental Biology. 1990 Oct; 28(10): 953-6