Role of nitric oxide in transmission of dengue virus specific suppressor signal.
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1997-08-01
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Production of NO2- was maximum when peritoneal M phi was incubated with SF (40 mg) for 45 min. Pretreatment of M phi with anti-SF-antisera inhibited production of NO2- Pretreatment of M phi with NG monomethyl L-arginine (L-NMA) or arginase, an inhibitor of L-arginine dependent pathway, inhibited production of NO2- and transmission of suppressor signal in a dose-dependent manner. This indicates that NO and Ca2+ serve as intracellular signal in transmission of DV-induced suppressor signal.
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Khare M, Chaturvedi UC. Role of nitric oxide in transmission of dengue virus specific suppressor signal. Indian Journal of Experimental Biology. 1997 Aug; 35(8): 855-60